一、 科目名稱: (Course Title) |
細菌致病機轉 7MT00070 |
二、 授課班別: (Class) |
7MT950A班
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三、 授課時數: |
2 學分(Credits) 2 小時(Hours)
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四、 授課教師: (Instructor) |
教師 (Instructor's Name) |
輔導時間地點(星期/節次/地點) (Office Hours) |
分機 (Extension) |
e_mail |
黃小萍 |
星期二/第五節/C310 星期二/第六節/C310 星期五/第三節/C310 星期五/第四節/C310
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07-7811151轉5318 |
SC069@fy.edu.tw |
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五、 先修科目: (Prerequisites) |
(無)
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六、 課程概述: (Course Description) |
本課程將以大腸桿菌、沙門氏菌與綠膿桿菌為實例,深入討論細菌的致病機轉。課程中將以基因體學為基礎,討論致病島群基因 (PAI) 的形成、演化,以及島群基因所攜帶的IS序列、tRNA與調節基因等,如何調控細菌毒性的表現。並進一步以蛋白體學,討論細菌毒素如何經由第一至七型分泌系統,與宿主細胞內蛋白產生各種的交互作用,以及細菌侵入宿主細胞後,如何脫離溶小體而寄生於宿主細胞內。這些細菌分泌的特殊蛋白,如何改變宿主細胞的激素分泌、細胞間訊息傳遞間,與宿主細胞正常的免疫防禦機制。 |
七、 課程目標: (Course Objectives) |
1.To understand the molecular mechanism in bacterial pathogenesis and a solid platform for more advanced courses. 2.To understand how information is acquired by experimentation and utilization of various information sources. |
八、 授課大綱: (Syllabus) |
單元主題 時數 Bacterial Genome and Pathogenicity Islands 4 Protein Secretion Systems 4 Binary Bacterial Toxins 4 Molecular Basis of Bacterial Outer Membrane Permeability 4 Quorum-sensing (QS) System and Biofilm 4 Phages and the Evolution of Bacterial Pathogens 4 Selected pathogen in Bacterial Pathogensis 12 |
九、 教學方法: (Teaching Methods) |
Lecture, Discussion and Report |
十、教材(教科書): (Teaching Materials) |
1. Microbiology And Molecular Biology Reviews, 2004-2007, Vol. 68-71. American Society For Microbiology. 2. Clinical Microbiology Reviews, 2004-2007, Vol. 18-21. American Society For Microbiology.
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十一、評值方法: (Evaluation Methods) |
Examination 50% Discussion 50%
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十二、參考書目: (References) |
1. Salyers AA, Whitt DD: Bacterial Pathogenesis- a molecular approach. 2nd 2002, ASM, Washington DC20036-2904, USA. 2. Cossart P, Boquet P, Normark S, Rappuoli R: Cellular Microbiology. 2000, ASM, Washington DC20005. 3. Brogden KA, Roth JA, Stanton TB, Bolin CA, Chris Minion F, Wannemuehler MJ: Virulence Mechanisms of bacterial pathogens. 2000, ASM, Washington DC20005. 4. Kathleen Park Talaro, Arthur Talaro, 2004, Foundations in Microbiology (Fifth edition) McGraw Hill
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十三、授課語言: (Language of Instruction) |
主要授課語言:國語 次要授課語言:英語 |
十四、教學型態: (Course Instruction Type) |
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請師生遵守智慧財產權,使用正版教科書,不得不法影印。 |